Metal porphyrinates, stable and biocompatible biological compounds, exhibit unique optical, mechanical, and magnetic properties when irradiated with infrared laser. The goal is to exploit these characteristics to develop a multi-theranostic approach, that is, combining diagnosis and therapy by creating innovative photofunctional nanoparticles that selectively penetrate tumor tissue. Using pulsed radiation in the near-infrared range, it would be possible to activate these nanoparticles delivered into melanoma and destroy tumor cells thanks to their photomechanical properties.
The project focuses on three key properties, activated by the laser:
Second Harmonic Generation (SHG): Useful for high-resolution bioimaging, the light emission of porphyrinates significantly increases with pulsed infrared laser irradiation.
Dynamic Behavior: The ability of some porphyrinates to move when irradiated could be used to selectively destroy tumor cells.
Induced Magnetism: Laser-magnetized nanoparticles can serve as contrast agents for MRI and as therapy (magnetomechanical or hyperthermic) to eliminate tumors.
The goal is to synthesize and coat new porphyrinate nanoparticles, optimizing their properties for targeted delivery to tumors. The multidisciplinary team from INRiM and the University of Turin will use advanced microscopy techniques for bio-tracking and early diagnosis, aiming at innovative therapies, such as the treatment of melanoma.
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